The Second District Conference was founded in Brooklyn, N.Y. in 1947 shortly after being transferred from the First District which included Massachusetts, Rhode Island and Connecticut.

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When formed the District was composed of five states: New York, New Jersey, Pennsylvania, Delaware and the Eastern Shore of Maryland.  When the newly formed District was transferred there were eleven chapters and in 1973 there were forty-four chapters (twelve undergraduate, three intermediate, and twenty-nine Graduate Chapters).